[PDF] Uncertainty quantification of the impact of peripheral arterial disease on abdominal aortic aneurysms in blood flow simulations | Semantic Scholar (2024)

The general role of the resistance and capacitance is clarified and the error of the flow rate ratios decreases exponentially as the resistance increases, and constraints on the parameters controlling the numerical stability of the simulations are established.

This work explains the concepts of global UQ and global, variance‐based SA along with two often‐used methods that are applicable to any model without requiring model implementation changes: Monte Carlo (MC) and polynomial chaos (PC).

It is proposed that the “high-versus-low wall shear stress” controversy is a manifestation of the complexity of aneurysm pathophysiology, and both high and low wallShear stress can drive intracranial aneurYSm growth and rupture.

It is shown for the first time that low shear stress at baseline is associated with both AAA expansion and future aneurysm-related events and aneurysms within the lowest tertile of shear pressure were more likely to rupture or reach thresholds for elective repair.

This paper presents a localised method for incorporating the effects of elastic walls into blood flow simulations using the lattice Boltzmann method implemented by the open-source code HemeLB, and demonstrates that the model can be used to efficiently and effectively represent flows in elastic blood vessels.

An extensive review of various approaches adopted to analyze the influence of blood rheological characteristics in a different class of blood vessels found the Carreau, Casson and generalized power-law models appeared to be superior for solving the blood flow at all shear rates.

Patient-specific computational fluid dynamics modeling of 10 small human AAA was performed to investigate relations between hemodynamics and ILT progression, finding regions of low OSI had the strongest correlation with ILT growth and demonstrated a statistically significant correlation coefficient.

The pathophysiology of TAAs and the role of mechanical stresses and mathematical growth models in TAA management are reviewed and a multiscale biomechanical analysis is applied to a case study of TAA.

The parameter that showed best correlation with the location of thrombus growth was the oscillatory shear index, and in the case of patient C where the interval between scans was the shortest, throm Bus growth was observed at regions of low oscillatoryShear index.

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